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Across different kinds of modern influences on human sleep-from communication and media technologies, to medical interventions and chemicals used to modify sleep and wakefulness, to the organization of social life-some are seen as...
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Across different kinds of modern influences on human sleep-from communication and media technologies, to medical interventions and chemicals used to modify sleep and wakefulness, to the organization of social life-some are seen as interfering with human nature. Others, like many institutions, are accepted as natural. This is apparent in the example of school start times, which are widely assumed to be based on an agrarian past. Unlike modern media technologies, school start times are often implicitly accepted as based in nature, and help constitute a sense of a historical primordial natural state in which humans lived in harmony with nature. The presumed naturalness of institutional times stands in opposition to modern media technologies and laboratory-derived chemicals, which are often criticized for being disruptive to our human natures and as having negative impacts on our sleep patterns. In some cases, technology may be serving as a distraction, interfering with a child's sleep, but technology also provides an easy object of criticism, for physicians, scientists, and parents. In doing so, normative social expectations and the institutions that frame them escape criticism in the face of blaming the disorderly behavior of individuals.
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A cultural imaginary identified as "fashion" links single women with problems of desire in contemporary India, setting the stakes not only for independent living, but also for the ways distresses may be read and treated. From cele...
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A cultural imaginary identified as "fashion" links single women with problems of desire in contemporary India, setting the stakes not only for independent living, but also for the ways distresses may be read and treated. From celebrity cases to films to clinical practices oriented around pharmaceuticals, the mechanisms of this imaginary locate female personhood at a series of critical junctures or "hinges," from pharmaceuticals to drugs of vice, from desire to expressions of disorder, and from singularity or independence to destitution. In each of these turns, as psychiatrists read female bodies for signs of affliction and media portray counter trajectories of aspiration and downfall, certain realities are shielded from consideration, including sexual violence in intimate settings.
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Pharmaceutical pollution in the aquatic environment is an issue of concern that has attracted attention by the news media. Understanding the factors that contribute to media framing of pharmaceutical pollution may lead to a better...
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Pharmaceutical pollution in the aquatic environment is an issue of concern that has attracted attention by the news media. Understanding the factors that contribute to media framing of pharmaceutical pollution may lead to a better understanding of the management and governance of this issue, including why these pollutants are generally unregulated at this time. This study conducted a content analysis of 405 newspaper articles (81 had substantive information on the topic) from 2007 to 2014, using the search terms "water" and "pharmaceuticals" in the Chicago Tribune, Denver Post, Los Angeles Times, New York Daily News, New York Times, USA Today, Wall Street Journal, and Washington Post. We sought to analyze the factors that contributed to the news media presentation of pharmaceutical pollution in the United States, including the presentation of the risks/safety and solutions by various actors. We found that the primary issues in the news media were uncertainty regarding public health and harm to the environment. The primary solutions recommended within the news media were implementing additional water treatment technologies, taking unused pharmaceuticals to predetermined sites for disposal (take-back programs), and trash disposal of unused pharmaceuticals. Water utilities and scientists presented improved water treatment technology, government actors presented take-back programs, and pharmaceutical representatives, while sparsely involved in the news media, presented trash disposal as their primary solutions. To advance the understanding of the management of pharmaceutical pollution, this article offers further insight into the debate and potential solutions within the news media presentation of this complex scientific topic.
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Pharmaceutical companies have traditionally marketed their products through a combination of several channels: sales details to physicians, direct-to-consumer advertising, professional medical journal advertising, sponsorship of m...
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Pharmaceutical companies have traditionally marketed their products through a combination of several channels: sales details to physicians, direct-to-consumer advertising, professional medical journal advertising, sponsorship of meetings and events and e-promotion. With an impending patent cliff and subsequent loss in revenue, the industry must depend on, among many factors, recently launched products to offset the revenue loss. Coupled with increased generic competition, companies must evaluate the return on investment of their marketing dollars. This paper analyzes the effectiveness of traditional marketing methods, both industry-wide and for recently launched products, using the latest Business Intelligent methods. The dataset used in this paper is a sample of prescription, promotional, competitive, and product data from SDI Health. The analysis in this paper reveals that traditional marketing methods have a decreasing level of impact with the number of prescriptions dispensed, and describes new potential channels for marketing, as well as collecting and analyzing data to aid the industry improve its resource utilization.
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A spectrofluorimetric study based on the metal-ion catalytic degradation of the alpha-amino beta-lactamic antibiotic ampicillin, in micellar media has been carried out. Different surfactant systems and metal ions were tested in or...
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A spectrofluorimetric study based on the metal-ion catalytic degradation of the alpha-amino beta-lactamic antibiotic ampicillin, in micellar media has been carried out. Different surfactant systems and metal ions were tested in order to enhance the analytical performance characteristics of the system. Results demonstrated that copper (II) ions were the most effective acting as catalyst and that the fluorescence intensity of the reaction products (measurement at 343 and 420 nm as excitation and emission wavelengths, respectively) was effectively enhanced in presence of anionic surfactants. Through variation of experimental conditions (temperature, pH, nature of buffer, reaction time) a selective and sensitive spectrofluorimetric batch method was developed for ampicillin determination. Also, a multisimplex design was used to determine the optimal values in a flow injection analysis (FIA) format and pH, flow rate and temperature were the variables considered. In the optimal experimental conditions, linear relationships were obtained, between intensity of fluorescence and concentration of ampicillin in the range of 2-10 muM for batch and flow systems and the detection limits were found to be 4.0 X 10~(-7) M and 5.2 X 10~(-7) M, respectively. The FIA method is rapid, simple, reproducible, selective and accurate within +-4.6% (6 muM ampicillin level). The method was applied to ampicillin determination in different dosage forms without interference effects.
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Cytostatic drugs have become one of the greatest environmental hazards. They exhibit toxic, carcinogenic, mutagenic and teratogenic effects on flora and fauna, including people. They are poorly eliminated in conventional wastewate...
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Cytostatic drugs have become one of the greatest environmental hazards. They exhibit toxic, carcinogenic, mutagenic and teratogenic effects on flora and fauna, including people. They are poorly eliminated in conventional wastewater treatment plants and their mixtures could possess higher ecotoxicity than individual drugs. Fungi are organisms with enormous potential for biodegradation of a variety of toxic chemical pollutants. The aim of this work was to estimate tolerance of five fungal strains to selected anticancer drugs, which will be useful to determine the potential for their possible use in cytostatics removal and may be significant in the context of wastewater treatment application. Test was conducted on Forces fomentarius (CB13), Hypholoma fasciculare (CB15), Phyllotopsis nidulans (CB14), Pleurotus ostreatus (BWPH) and Trametes versicolor (CB8) and the chosen drugs were bleomycin and vincristine. Their ability to grow in the presence of selected cytostatics was evaluated in cultures conducted on two solid media which differed in the richness of nutrient compounds. Fungal strains tolerance was expressed as a half maximal effective concentration.
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In 2012 and 2016, the first two strategic science-business media models were published (SBBMM 1.0 and 2.0). Since that time, there have been significant changes both to the media landscape and to the usage and capability of online...
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In 2012 and 2016, the first two strategic science-business media models were published (SBBMM 1.0 and 2.0). Since that time, there have been significant changes both to the media landscape and to the usage and capability of online and social media platforms. This paper seeks to describe the current bioindustry-relevant media landscape, to introduce a new media model, the Strategic Bioenterprise Media Model 2020 (SBMM 2020), which reflects this new landscape, and to present a mainstream submodel to support the latest opportunity for biotechnology media coverage: Mainstream Media. Examples are drawn from media coverage following the FDA approvals of Zulresso from Sage Therapeutics, Aimovig from Novartis and Amgen, and AquAdvantage salmon from AquAdvantage Technologies. The overall goal of this paper is to equip bioenterprise professionals with an understanding of media dynamics and the strategic potential it brings, ultimately contributing to bioenterprise success.
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The toxicological assessment of medicinal products (MPs) and their residues and metabolites in the environment have become a challenging task worldwide. The contamination of environmental compartments, biota, workplace, foodstuff ...
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The toxicological assessment of medicinal products (MPs) and their residues and metabolites in the environment have become a challenging task worldwide. The contamination of environmental compartments, biota, workplace, foodstuff and feedstuff by residues and metabolites of these substances poses a risk to human health which is still far from being fully understood. On the other hand, existing analytical methods not always possess sufficient detection power to quantify residues of MPs at very low concentrations. This review sets forth some of the most significant contributions made in this field over the past decade with a special focus on novel fit-for-purpose analytical approaches for the detection, identification and quantification of these pollutants and the assessment of their noxious potential for human beings and the environment. (C) 2014 Elsevier B.V. All rights reserved.
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Aims An increasing number of women trust the Internet for information about medication safety during pregnancy. This study aimed to evaluate the availability and accuracy of social media content on the perceived safety of medicati...
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Aims An increasing number of women trust the Internet for information about medication safety during pregnancy. This study aimed to evaluate the availability and accuracy of social media content on the perceived safety of medication use in pregnancy. Methods We performed a systematic search of posts related to medication safety during pregnancy in the Dutch language published on social media, blogs and forums between May 2011 and April 2016 using Coosto, a tool for social media monitoring. The perceived safety in the posts was compared with the Dutch Teratology Information Service (TIS) safety classifications. Results We included 1224 online posts, which described 1441 scenarios about medication safety in pregnancy. A total of 820 (57%) scenarios were in line with the TIS classification. Incorrect perception was higher for prescription medication compared to medication available over‐the‐counter (60 vs 25%). Furthermore, the safety classification of medications with a TIS classification on strict indication or second‐line drugs (93%) and medications with insufficient knowledge on their safety during pregnancy (76%) was more likely to be incorrectly perceived by the public compared to medications with the TIS classification safe (24%). Conclusions Social media monitoring may be useful for surveillance of potentially unsafe use of medications in pregnancy. Many social posts related to medication safety during pregnancy provide inaccurate information. As this information may affect women's perceptions and decisions, accurate communication between healthcare providers and pregnant women regarding the benefits and risks of medications is vital.
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